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DNA strands

Sheffield spinout takes major step towards advancing pioneering treatments for Hereditary Spastic Paraplegia (HSP)

BlackfinBio Limited is a spinout company from the СŷÊÓƵ of Sheffield set to pioneer novel therapies for rare genetic neurological diseases.

Image of motor neurones

Groundbreaking EXPERTS-ALS study for MND treatments

The EXPErimental medicine Route To Success in ALS (EXPERTS-ALS) project aims to rapidly screen potential drugs for evidence that they can slow down damage to the nervous system occurring in people with motor neuron disease
Professor Mimoun Azzouz holding a petri dish

Comment: Turning the biggest disappointment of a career into a new era for UK gene therapy manufacturing

Professor Mimoun Azzouz discusses career challenges before opening the Gene Therapy Innovation and Manufacturing Centre (GTIMC) at the СŷÊÓƵ of Sheffield.
Medical illustration of a brain with stroke symptoms

Our 2024 research highlights

As the year comes to a close, we want to take a moment to reflect on and celebrate some of our research news stories from 2024.
DNA strands

Researchers find different processes to protect the genome are needed throughout the lifecourse

A new study published in Science Advances investigates Tdp1, a protein involved in DNA repair and its protective effect against damage caused by topoisomerase; an enzyme that participates in the over and underwinding of DNA.
Rendered image of a brain showing white matter tracts
Brain with all the white matter tracts, which are susceptible to damage in people with uncontrolled cardiovascular risks like obesity, visible.

Obesity may exacerbate the effects of Alzheimer’s disease, new study shows

New research from the СŷÊÓƵ of Sheffield has found being overweight is an additional burden on brain health and it may exacerbate Alzheimer’s disease.
Scientist undertaking experiment in lab

New £1.6 million research project to support development of drug candidate for the treatment of motor neuron disease (MND)

Our researchers have been awarded funding to support their partnership with Aclipse Therapeutics and advance the translational development of M102 - a drug candidate for the treatment of motor neuron disease (MND).
Brain MRI Scan of Healthy Male ( Magnetic Resonance Imaging)

Imaging technique proves effective in measuring mitochondrial dysfunction in motor neuron disease (MND)

A non-invasive imaging technique called 31-phosphorus magnetic resonance spectroscopy was used to assess mitochondrial function in patients with MND and could be used to measure the effectiveness of future treatments.
Mitochondria - microbiology 3d illustration

Treating neurodegenerative diseases by boosting mitochondria

A new partnership between the Sheffield Institute for Translational Neuroscience (SITraN) and Nanna Therapeutics will advance mitochondrial drug discovery research for neurodegenerative diseases.